Dear Peter,

Although Sticky platelet Syndrome (SPS) was discovered in 1983, it did not gain much recognition until 1995 when Dr. Bick added an SPS evaluation to the patients who were referred to him for evaluation of causes of arterial and venous thrombosis.  In his experience SPS accounted for nearly 21% of otherwise unexplained arterial events and 13.2% of otherwise unexplained venous events.  Given that a majority of patients take aspirin on a routine basis for the prevention of cardiovascular complications, the true incidence of SPS may not be known, since aspirin usage may mask SPS.

Omer

Dear Peter,

I consider SPS as an important cause of  threatening complications. We have seen some young people with SPS, suffering from ischemic stroke or cerebral sinus thrombosis.

Petr

Dear Omer,

Please see our publication : "Sticky Platelet Syndorme : History and Future Perspectives" in Semin Thromb Hemost 2014;40:526-534 and also previous publication in the Semin Thromb Hemost 2013;39:674-683. It seems that SPS is multigenetic disorder and probably, we have two distinctions : inherited and acquired SPS. To be more precise, we also speak about SPS phenotype.

Peter 

See our review and recommendations for the diagnosis and treatment of SPS