Because I am interested to carry out any biological applications for my complexes. What type of biological application can I take and it will be useful to the society?
yes. Some metal complexes posses good antic cancer activity like five membered ring containing nitrogen. for example platinum complexes...
cis platin (NH3)2PtCl2 has anticancer activity as its square planar geometry helps it chelate to DNA and stops DNA repaair. There is an Au complex that is effective against rheumatoid Arthritis (Auranofin), a Tc complex for heart imaging (Cardiolyte) and Mn(II) and Gd(III) complexes as MRI contrast agents (Magnevist, Omniscan, Teslascan).
Besides cisplatin, many 2nd row transition metals will bind to DNA once they thermally exchange with water. Many compounds are currently being studied that exchange upon photodissociation such as Ruthenium(II) and (III) and some Rhodium compounds. The metals bind to the DNA base pairs -- I included a picture from a paper authored by Jan Reedijk titled "Fast and slow versus strong and weak metal–DNA binding: consequences for anti-cancer activity" that shows a few possible binding sites of Pt and Ru based drugs to the soft nitrogens of the DNA bases.
Finding a metal that has anticancer properties is hard to find because they do not bind selectively, and many have trouble transporting the cell membrane due to their charge. This makes the chemotherapy non-selective and has fallen out of favor in the research. Photodynamic therapy is one way that you can bind a drug to a metal to create a dissociation event where light is shown. Thus the metal acts like less of a therapeutic and more of a method of selective drug transport.
To answer your question, I think that metal complexes can be relevant in research and to the field of medicine, and a metal complex itself could lead the charge. However, it is difficult to design a metal complex that is selective for only cancerous cells. Thus, looking at a light/pH/magnetization induced therapeutic effect is neccessary.
See for example
"Photoinduced ligand exchange and DNA binding of cis-[Ru(phpy)(phen)(CH3CN)2]+ with long wavelength visible light"Sears R Bryan; Joyce Lauren E; Ojaimi Maya; Gallucci Judith C; Thummel Randolph P; Turro Claudia. Journal of inorganic biochemistry (2013), 121, 77-87.
http://www.rsc.org/ej/MT/2012/c2mt20032e/c2mt20032e-f1.gif
As well as cisplatin, carboplatin and some other Pt drugs are already in clinical use. One problem with cisplatin is that some people develope an allergy to it, for those people it is often a good idea to switch to carboplatin.
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