Dear colleagues, please lmn what volume do you use for intranasal instillation in rats?

Maria Diana Moreira Gomes @Maria_Moreira_Gomes

02 February 2019 1 2K Report

I am in doubt as to the best volume for intranasal instillation in rats, what volume ensures the best distribution of the particles?

Siddhartha Dutta

Take a look at these articles. These might help you.

1. Southam DS, Dolovich M, O'Byrne PM, Inman MD. Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia. Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L833-9. PubMed PMID: 11880310.

2.https://www.bu.edu/researchsupport/compliance/animal-care/working-with-animals/procedures/administration-of-drugs-and-experimental-compounds-in-mice-and-rats/

3.Article Visualization of Murine Intranasal Dosing Efficiency Using L...

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