Can we compare the NexIon 2000 ICP-MS of Perkin Elmer with QID technology with other triple quadrupole ICP-MS of Thermo and Agilent or any other make?

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Matthew Wheal

According to the brochures - yes (https://www.perkinelmer.com/product/nexion-2000b-icp-ms-configuration-n8150044).

However I believe they take a small liberty by calling the Quadrupole Ion Deflector the first quadrupole, when it mainly redirects the ions 90°. Regardless of how it is labelled, this triple quad design (in the earlier model Nexion350 which I use), is quite effective over an enormous range of elements and concentrations, often simultaneously.

From the Nexion5000 webpage (https://www.perkinelmer.com/product/final-assy-nexion-5000-n8160010) which claims to have :

Four quadrupoles:

First: Quadrupole Ion Deflector (Q0) directs ions to the entrance of the first mass filter

Second: Transmission Analyzer Quadrupole 1 (Q1, full-sized for

Bodo Hattendorf

Dear Geetgovind Sinam

Considering the basic functions of theses instrument they are interchangeable.

The nomenclature of "triple-quadrupole" however would actually require 3 quadrupoles in series, which is not the case for the Agilent instrument.

That's why I prefer the term MS/MS when using that instrument with the reaction cell pressurized.

But considering the basic processes, it does not make much of a difference because the 2nd quadrupole is usually operated in a bandpass mode similar to an octa- or hexapole. The dynamic badnpass tuning mentioned by Matthew Wheal is in my opinion not really required anymore because the first mass filter will take care of the secondary chemistry in more efficient way.

With best regards

Bodo