By book definition, relative bio availability is comparing a given formula to a standard. But this is usually used for different dosage forms other than IV. So my question is, can we compare a given formula to a standard when are administered intravenous.
the bioavailability of IV giving drug should be a 100%. but for you case I think you need to calculate the F% of oral administration of a drug and IV administration and use the the formula F% = AUC oral / AUC IV x 100
Dear Sara,
If you make a comparison two PK profiles after IV administration (for example bolus with the same dose and drug substance but from different vendors) still you make comparison of data which reflects two fully available products. Its not bioavailability study because both substances immediately after injection are in the bloodstream. Its not absolute F analysis (because its not IV versus oral for example) and its not relative F (because its not subcutaneous versus intraperitoneal for example). You can name your analysis "relative F" only in case when IV is not available. Please check page 3 of this document:
http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003519.pdf
Hope it will be useful, best regards
Tomasz
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