Can phenylalanine do hoffmann elimination to give trans-cinnamic acid ?

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Ian M. Henderson

Article STUDIES ON NITRATED PROTEINS: I. THE DETERMINATION OF THE ST...

Jürgen Wintner

maybe this gives you an answer:

Olefins from Amines: The Hofmann Elimination Reaction and Amine Oxide Pyrolysis

http://onlinelibrary.wiley.com/doi/10.1002/0471264180.or011.05/abstract

Soufiane Touil

In theory Yes. You can try the following conditions: i) MeI (3 equiv), K2CO3 (4 equiv), H20; ii) Ag2O (1 equiv) then heating; iii) HCl cc. The Z isomer could also be obtained as minor product.

Good luck.

Shivansh Mahajan

Thanks for all the responses.