Yes/No, your questions is unspecific. You can simulate every system which you can describe. The simulation improves your understanding of the modeled system. If you are capable to describe your system model, by an algorithm or a set of equations than yes it is possbile to simulate your detection system.
Anothor question is, how much effort do you need to simulate your system. You not only need your system, you also need the environment.
Yes, Intruder detection is obviously possible using tje neuro-fuzzy toolbox. But, the point is a simple intruder detection system does not need the complex neuro-fuzzy tool. Only the Fuzzy toolbox is enough to build such a system. The fact is you need to specify the parameters first for an intruder detection. After specification of the parameter, you can develop choose the simulation platform.