1. Ferrocene (Fc) in reduction state could from host-guest complex with β-CD, while the oxidized Ferrocene (Fc+), as reported by many papers, could not stay in the cavity of β-CD due to the decreased affinity between them.
2. Benzimidazole could complex with β-CD under neutral condition, while under acid environment, the protonated benzimidazole escaped from the cavity.
Based on these facts, can I conclude that unfunctionalized β-CD could not complex with positively charged molecules, such as quaternary ammonium?
Has someone ever seen such host-guest system?
THANK YOU ALL FOR YOUR ATTENTION! :)
Beta-cyclodextrin can complex with quaternary ammonium type compounds through the hydrophobic interactions of its cavity, so amphiphilic QAC such as alkyl or benzyl derivatives are found to form complexes. Interaction is produced by the hydrophobic tail and cavity.
I am adding a review that you can find useful.
Good luck!
Article Encapsulation of biocides by cyclodextrins: Toward synergist...
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