Can Arsenic be non-toxic at 10mg/kg in rat when administered alone but becomes toxic when administered along with vit. C
This is probably due to some other factors you did not take precaution on.when vit c + arsenic was administered. or the dosage was not properly calculated or the route of administration?
The answer could be that As was administered as As(V), which is less toxic than As(III). Addition of ascorbic acid has reduced As(V) to As(III) and thus, increased the toxicity of the metal.
I don't think whether you administered AsV or AsIII makes that much of a difference actually, because AsV is reduced rapidly in blood to AsIII. That in turn could depend on how you administered it. Also, under certain conditions ascorbate can be a pro-oxidant, which in theory would potentiate the toxicity of arsenic
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