Hi we are working on kinetics of propofol injection and would like to know the dissolution media conditions. if anyone is having any idea pls. suggest us.
Usually you don't need to dilute propofol W/O emulsion, but this can be done using sterile NaCl 0.9% or dextrose 5% for injection as diluent, maximum dilution is 1/5 (1 volume propofol + 4 vol diluent)
You can refer USP General Chapter requirements, similar to the proposed labels for the 50 mL and 100 mL vials. You can refer uploaded attachment for the better view.