We're trying to synthesize Fluorescamine [38183-12-9] from 1,3-Indanedione and would love to know if anyone has had any experience with this kind of synthesis. Any suggestions, recommendations ?
I wasn't able to access the source posted by Ramin Javahershenas so here are a few other options.
There is a JACS paper (link below; J. Am. Chem. Soc.1972, 94, 16, 5927-5928) and a patent US4304715 (link below).
Is there a reason you're starting with 1,3-Indanedione?
Article Novel reagent for fluorometric assay of primary amines
http://patft1.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=4304715.PN.&OS=PN/4304715&RS=PN/4304715
Grant Simpson
We received an indication that the starting reagent was 1,3-Indanedione. Do you you recommend another starting reagent?
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