How can I calculate the used dose of substance in vivo (intratesticular) after determining the effective dose of it in vitro (on semen sample)?
Say, if 3 mg of a substance is effective to kill sperms in vitro study, how much mg we have to use in vivo (intratesticular) for chemical sterilization?
Hussein Awad Hussein
Hi Dear Ahmed,
I think you can prepare different concentrations of this substance, then you can try each concentration in vivo. After that, you have to carry out semen analysis and sperm count, then based on the results you can select the appropriate concentration or mg of the substance.
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