I am not sure but I think having unresolved issues from their youth tend to make them anxious and worrisome nearing the end of their days, which can lead to strange behaviours to include loss of appetite. I think it is indeed an area that needs more research.
Psychiatric disorder studies are very vague as every brain is different. There are many biomarkers which are not known still for psychiatric disorders. If the biomarkers are known, then much copacetic studies including the pathway analysis using a Systems Biology approach or drug discovery screening using NGS approaches can be carried right away.
These missing loopholes can only be fixed we wet-lab joins their hands with the computational intelligence, such as- BIOINFORMATICS/ CHEMINFORMATICS.
Peripheral personality disorder is a type of personality disorder of group B, one of the most prominent symptoms of which is characterized by a characteristic impulse and an imbalance in the expression of emotions, relationships with people, and self-image. This disease is classified as a diagnostic and statistical guide to mental disorders. Other symptoms of this disorder are fear of abandonment, and severe episodes of anger. In addition, they may harm themselves or commit suicide.