Dear Colleagues,

Apparently, a trigger is desirable for starting the discussion.

The discovery mentioned in this question means that the thermodynamic and chemical grounds of the theoretical biology should be revised. It is possible to turn a blind eye to this fact. But this will be made sooner or later.

The notion of the synthesizing of biological products through the preliminary synthesis of adenosine triphosphate for using its energy in subsequent syntheses of different bio-substances is commonly accepted. But what is the reaction that gives the energy necessary for ATP synthesis? Maybe it makes sense to include this reaction into the bio-cycle, if it exists and is identifiable? Not only thermodynamically impossible final biological products but also thermodynamically impossible intermediates cannot be synthesized. Protein, apparently, can be synthesized without ATP; this is shown in one of our papers listed below. What particular products entering into the bio-cycle cannot be synthesized without ATP? Maybe it makes sense to return to this question? If a set of source substances is thermodynamically capable of forming a product and the process of its formation is multistep, the synthesis of a final product should proceed through stepwise decreasing in the free energy. On the contrary, if synthesis of a product from a set of source substances is thermodynamically forbidden, no change in the sequence of reactions between these source substances is capable of synthesizing the product.

Enzymes, thousands of different types? What are the forces and circumstances that compel them to be synthesized? By what way are they capable of occurring in a necessary moment at a necessary point? What is about the diffusion laws? What makes them do the work that is attributed to them?

The first physicochemical explanation of the phenomena of DNA replication and mitosis was given in our works available in my ResearchGate pages by the addresses:

https://www.researchgate.net/publication/235409468_Mitosis_and_DNA_Replication_and_Life_Origination_Hydrate_Hypotheses_Common_Physical_and_Chemical_Grounds ,

https://www.researchgate.net/publication/235343147_Hypothetical_physicochemical_mechanisms_of_some_intracellular_processes_The_hydrate_hypothesis_of_mitosis_and_DNA_replication ,

https://www.researchgate.net/publication/288664181_Natural_Mechanism_of_Origination_and_Conservation_of_Monochirality_of_Amino_Acids ,

https://www.researchgate.net/publication/266393167_OPTIMAL_NUTRITION_AND_CELLULAR_LIFE_PROLONGATION_IN_THE_LOH-THEORY_CONTEXT ,

https://www.researchgate.net/publication/235342937_Life_Origination_Hydrate_Hypothesis_LOH-Hypothesis ,

https://www.researchgate.net/publication/235354873_Life_Origination_Hydrate_Hypothesis_LOH-Hypothesis_Original_Approach_to_Solution_of_the_Problem ,

https://www.researchgate.net/publication/282252161_Life_Origination_Hydrate_Theory_LOH-Theory_Thermodynamic_and_Kinetic_Factors_in_the_Natural_Mechanisms_of_Amino-Acids_Origination

and in other our works on this problem.

Don’t you like our explanations? Why?

Please, propose another physicochemical explanation of these phenomena.

Without an adequate physicochemical description of a phenomenon, there is no science.

Prof. Hervé Seligmann, a scientist highly experienced in different biological problems, the author of many important publications, and the editor of the book “DNA Replication – Current Advances” (2011), wrote in the Preface to this book:

«But perhaps the most astonishing and challenging novelty in this book is the approach of DNA structure and chemical dynamics by focusing on its interactions with its natural solvent, the water molecules, and the changes in water concentrations through the cell’s life cycle (chapter by Ostrovskii and Kadyshevich). This most interesting hypothesis develops a concept that escapes conceptions established through the force of habit, which frequently result in dominant, yet unproven intuitive truths. This hypothesis will doubtlessly produce new deep insights into every level of DNA associated processes, and probably also general cell physiology, if given the deserved consideration and further developed. The approach in that chapter integrates processes associated with DNA and its structure with more basic physical properties at a lower scale of natural phenomena, namely the multimolecular dynamical structure of water.»

However, up to now, I don’t see bold spirits, which are ready to devote their time and energy to development of physicochemical understanding, including thermodynamic grounding, of driving forces of those processes which underlie the life development and dying. I ascribe this situation to the system of financial support of the mainstream hypotheses to the prejudice of principally new ideas, what was always a feather in science's cap.

Victor Ostrovskii !!!

Impressively long answer.

Dear Colleague Vasili Dimitrov,

Thank you for your remark.

Yes, of course, each living issue is under the heat/mass exchange with the environment and, when writing that bioprocesses are thermodynamically caused and require no energy input, I keep in mind the processes of syntheses of bio-issues from minerals in the context of our hydrate theory of living matter origination and, of course, the processes within the organisms as such. This was my terminological mistake in English and I thank you very much for its correction.

Best regards.