I used diethyl 2-fluromalonate and diethyl 2-aminomalonate as a starting materials. Both of this were saponified with methanolic sodium hydroxide (2 M, 3.5 mL) in dichloromethane and methanol (9:1 v/v, 32 mL) and the sodium salt isolated by filtration through a Büchner funnel with a fine porosity glass frit. Once I did the all procedure, injected into mass but i couldn't detect the mass of corresponding acid.
I will be very grateful if any one suggest an efficient method for the synthesis of these two acid. Thanks much in advance.
Dear Kamal Adhikari thank you for your interesting technical question. Why do you expect to see the free acid in the mass spectrum when you have the sodium salts? I think you first need to isolate the free acids. I assume that you could acidify aqueous solutions of your sodium salts with HCl or H2SO4 and extract the free acids with diethyl ether. After drying and evaporation of the solvent, fluoromalonic acid can be purified by sublimation (see attached article).
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