Hi 

if your question is about peptide chemistry, the attached paper could help you.

please follow my article i hv used s-s cyclisation by iodine oxidation method

Dear all,

i meant theoretical work..!

We use Yasar to build and make molecular simulations of uor cyclic peptides.

http://www.yasara.org/

chem draw software..... for

Julio,

thanks for the suggestion,is it possible to make cyclic peptide ring using this software ,im able to make linear chain but couldnt get how to get cyclic form,any manual or tutorial available?

Regards

Nikhil

Marvin Sketch

may i know how long ur peptide is? if it is 10-20 mer u can draw in chem draw.

and 2ndly which kind of cyclisation ur interested? if S_S bond formation then it can be performed and ankyne -azide cyclo addition can alsobe done after drawing just select the molecule- go to structure-select check structure and clean structure then u will get the cyclic peptide.

Hope this would be work for u.

 Ashok,

6 amino acids connected and want to make cyclic peptide

then just do it in chemdraw its simple and save in .mol format and convert it as per ur desired file format in desmond or any softwear

its simple jst c my publications i too synthesised and draw the molecule in chemdraw

chemdraw only 2d is possible,right?

yes brother in chem draw 2D structure but in chem 3D u can view 3D  structure i chem office package u will get it... jst draw the structure in chem draw save it in .mol format and open in chem 3D... thts it..... hope now u understood....

best up luck

What is the number of residues of your peptide??

Eci Veerman,

6 

It depends on the kind of cyclization you want. If for instance, you want to join the terminal amino and carboxylate terminals, using Marvin sketch, you can simply drag the N-terminal amine to the C-terminal -OH of the -COOH. Then clean in 2D. You'll get your cyclized peptide. Be sure to activate structure checker to "automatic" to help you fix errors.