The global increase in multidrug-resistant (MDR) bacterial infections presents a serious public health challenge, making many conventional antibiotics less effective. In response, extensive research has focused on the development of alternative, non-antibiotic strategies that act through mechanisms distinct from conventional antimicrobial pathways. The most prominent approaches include:
We were warned about MDR in 1913 by Ehrlich. His solution (prevention of MDR): use high lethal doses for shorter periods, use combination therapy. The best way to avoid abx overuse is to reduce infection (by asepsis and antisepsis) but bacteriophage therapy should be given more attention. More "new" abx is not really the answer if they are to be used in a conventional therapeutic regimen, ie doses based on MIC (non-lethal) and longer courses, and monotherapy. See the record of abx in terms of date of release to date of resistance- often months or 1-2 yrs. It is commercially not worth the investment.
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