Why is the yield of using the 2-fluoroboronic acid coupling with 4-methoxylisatin much lower than using 4-fluoroboroic acid?

I am synthesizing the compound 1 by using chan-lam reaction as the figure showing. However, the conversion yield of ortho fluoroboronic acid (less than 20% on LC/MS) is much lower than the para...

02 June 2019 3,166 9 View