Is the conserved active site cysteine residue (Cys208) of NDM-1 β-lactamase a good drug target for covalent inhibitor development?

The Zn2 site of class B1 β-lactamase contains a conserved cysteine residue, Cys208 in NDM-1, required for Zn2+ binding. The disruption of Cys208 for Zn-coordination may effectively inhibit the...

19 March 2022 3,782 2 View