Wing-Leung Wong

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Questions related from Wing-Leung Wong

Is the conserved active site cysteine residue (Cys208) of NDM-1 β-lactamase a good drug target for covalent inhibitor development?

The Zn2 site of class B1 β-lactamase contains a conserved cysteine residue, Cys208 in NDM-1, required for Zn2+ binding. The disruption of Cys208 for Zn-coordination may effectively inhibit the...

19 March 2022 3,817 2 View

Are G-quadruplex structures of RNA and DNA good drug targets of small-molecule ligands?

G-quadruplex structures of nucleic acids have been a focus of study for anticancer or other diseases therapy for long time. Nonetheless, there is still no G4-targeting drugs available for clinical...

01 January 1970 9,130 1 View