Vishnu Kiran

5 Questions 19 Answers 0 Followers

Questions related from Vishnu Kiran

How to overcome hydrolysis of drug in Nanoemulsion?

Hi, My drug is sensitive to hydrolysis and we are trying to formulate an o/w nanoemulsion of it. In the stability study, we see a degradation of the drug due to hydrolysis which is not acceptable....

07 July 2018 8,171 4 View

Can THF be used as organic phase solvent in nanoprecipitation method of preparing polymeric nanoparticles?

Can I use THF to dissolve the polymer and drug in organic phase for preparing PLGA/PCL nanoparticles by nanoprecipitation method? are there any drawbacks of using THF?

03 March 2015 3,139 2 View

What could be the reason for low entrapment efficiency of a lipophilic drug in PLGA nanoparticles?

I have used PLGA (50:50) of different molecular weight ranges (low-high) to entrap a lipophilic drug by nanoprecipitation method. The %EE obtained by HPLC analysis shows nothing has been...

03 March 2015 2,492 7 View

What kind of equipment would be required to scale up lipid nanoparticles/liposomes/multivesicular injectable systems from lab to industrial scale?

We are planning to scale up (lab-to-industry) lipid based nano injectable systems. Kindly suggest what sort of processing equipment/technology (Microfluidizer? or any other?) helps meets the...

02 February 2015 1,723 4 View

How can I get maximum yield of PEG-PLGA diblock copolymer using EDC/NHS coupling reaction?

I have tried synthesizing PEG-PLGA diblock copolymer using traditional EDC/NHS reaction. The problem here is the yield of the final product. It was around 20%. What could be the reason for this?...

02 February 2015 5,461 7 View