Do I need to neutralize EDC-HCl for amide coupling?

I am doing a coupling reaction using naphthyridine dicarboxylic acid and 2-aminomethylpyridine using EDC HCl, HOBt, DMAP and DMF. Do I need to add base to neutralize the HCl salt before, during or...

17 January 2015 9,846 4 View