Thomas Andl

4 Questions 144 Answers 0 Followers

Questions related from Thomas Andl

What is a good way to synchronize primary human epidermal keratinocytes (NHEK)?

I was wondering whether someone has a protocol to get decent cell cycle synchronization of normal human keratinocytes in vitro. I had done a double thymidine block with HaCaT cells but I am not...

05 May 2017 8,304 5 View

With regards to P53 co-expression with proliferation markers, is mutant p53 stabilization regulated by proliferation?

In my experience, p53 protein is often co-expressed with proliferation markers such as Ki67. How does this work? Is there mutant p53 expression in quiescent cells, and if not what are the factors...

09 September 2014 5,804 4 View

What does Peto's paradox really mean? Are mouse tumor studies relevant?

Peto's paradox states: "There appears to be no correlation between body size, longevity and cancer across species and the absence of such a relationship is referred to as Peto’s Paradox". Example:...

08 August 2014 7,141 4 View

Which human tissue has the highest cancer incidence when normalized to size of the organ?

Based on the surface area of about 1.9 m2 and 3.5 million new cancers per year (Squamous cell carcinoma and basal cell carcinoma) the ectocervix has a very high cancer rate per m2 surface area:...

08 August 2014 10,055 6 View