Spencer Keene

6 Questions 7 Answers 0 Followers

Questions related from Spencer Keene

Manual calculation of interaction p-value?

Hello, I was wondering if there was a way to calculate interaction p-value by hand using estimates from a published article that does not report the p-value?? For instance, if the HR (95% CI)...

05 April 2023 5,588 1 View

Translating two biomarkers to the same scale??

Hello researchers, I was wondering if anyone had experience in the following: I would like to translate two separate continuous biomarkers (A and B), that are mechanistically linked to each...

26 January 2021 2,484 3 View

Is there a clinically relevant increase in predicted mortality after use of prediction rules?

This might be a stupid question but hear me out if you have time. Prediction rules (a.k.a multi-component prediction scores/indices) give individual-level predicted risk of mortality within a...

18 March 2019 1,344 2 View

How do you include time-varying covariates in repeated measures mixed effect models?

Hello, I have noted contradictory advice from statisticians on how to model time-varying covariates in a repeated measures mixed effect model. For instance, you may have BMI measured every month...

17 December 2018 6,332 5 View

Mixed effects and baseline response?

Mixed effect model and baseline dependent variable as covariate I would like to determine which predictors are associated with the rate of change in a continuous dependent variable...

29 April 2018 8,735 4 View

GEE or mixed methods? Which statistical method is best with a open-cohort repeated measures design?

I want to start a study that repeatedly measures a factor across time and looks at its change by certain patient subgroups. Of course I want to account for dependence between observations at...

23 January 2018 2,208 6 View