Does anyone have experience with loading Fmoc-Cys(Acm) to Chlorotrityl resin? Can you suggest the best protocol?

I am achieving 92% loading with Fmoc-Cys(trt)-OH with the same protocol and only 40% with Fmoc-Cys(Acm)-OH. Already, I had coupled other standard amino acids with loading efficiency more than 80%....

11 November 2012 5,517 1 View