Shaobo Zhang

6 Questions 11 Answers 0 Followers

Questions related from Shaobo Zhang

Does same gene dose mean same amount of expression?

My question is on the way of expression of allele specific copy number variation, e.g. individual 1 has a CNV as 3, 3, on each allele, with 6 copies; and individual 2 has 1, 5, on either allele,...

29 February 2024 1,636 1 View

Experiences on comparison in real time PCR and digital PCR in copy number test?

I used to work on copy number test using Taqman real time PCR and now transfer to digital PCR. I am wondering if anyone had experiences in comparison on same cohort between real-time and digital...

20 October 2023 1,218 1 View

Gene dosage and protein expression are linear corelated?

I am interested in the relationship between gene dosage and the amount of protein expression. Any one has experience in this concern? If there is a consensus?

18 July 2023 6,386 4 View

Addressing the tumor with multi/oligo-clonal origin or sub-clone evolution challenges?

It is suggested that tumors frequently show oligoclonal origin, moreover, cell evolution produced more genetically related but different cell clones. Those about mentioned clones raised new...

03 December 2018 4,925 0 View

Clear cut definition for genetic variant and mutation?

There are a lot of articles talking about genetic variant and more talking about mutations. At this stage if we have a clear cut definition which could clearly differentiate the variant and mutations?

13 April 2017 1,215 8 View

How to determine if a genetic mutation is a driver mutation for a specific tumor?

We all have experiences that more and more mutations are found in tumors. A few of them are recurrence (driver mutations) but most of them are not. The problem is how to determine a mutation...

11 February 2015 2,937 7 View