4 Questions 3 Answers 0 Followers
Questions related from Sander W. Van der Laan
Hi, I'd like to analyse Genetic-Variation-to-CpG correlations, i.e. methylation QTLs (meQTLs). Obviously the distribution of methylation (beta-value) of any one CpG-probe is not-normal and heavily...
29 December 2015 1,417 2 View
We've run GWAS on special traits. Unfortunately our cohort is unique in its kind. We cannot replicate. We can only validate and verify results in the context of other (related) traits or find...
27 October 2015 2,189 7 View
As usually GWAS/ExomeChip data is encoded as chr:bp or with a rsID, I'm looking for an easy method to interpret those "pharmacological variants" like CYP2C19*2.
27 October 2015 6,218 7 View
Often I see papers where they use "inverse normal transformation" to transform a not-normally distributed trait. I understand why you'd want to transform. But what is the advantage of using...
23 June 2015 7,296 3 View
