Sachin Bhatt

7 Questions 6 Answers 0 Followers

Questions related from Sachin Bhatt

How to evaluate ligand docking, docked at two different ligand position?

I facing a difficulty in evaluation. I had two ligands in proximity binding on a protein, rather targeting individual target i prefer to chose both ligands ( grid generation and docked molecules...

08 February 2022 469 3 View

How to add Post-transnational modification in modelled protein?

I have a protein that had missing loops, when the loop was modelled, the PTM had gone missing. Now I want protein with PTM along with loops for further analysis. Please suggest. Thank you in advance.

17 November 2021 7,855 2 View

How to construct a loop in protein?

I have a protein, but one of its loop has be modeled as similar to a template protein. How can i proceed with this?

16 November 2021 4,839 6 View

How to minimize protein in maestro ?

Hi, I have been trying to minimize a protein showing invalid bond type in some residues. while minimizing it throw an error "restrained minimization has failed". please help thanks in advance.

15 November 2021 659 2 View

How to find Kd value in Maestro?

I have an enzyme with an active site. I want to bind a specific ligand to the site and calculate the Kd value in Maestro or any other program. Also is it possible to mutate the interacting...

08 November 2021 7,322 2 View

How to find Kd Value of a ligand bound to an enzyme?

I have an enzyme with an active site. I want to bind a specific ligand to the site and calculate the Kd value in Maestro or any other program. Also is it possible to mutate the interacting...

08 November 2021 7,424 4 View

How to find binding sites of an apo structure by comparing with available co-crystallize structure sharing the structural identity?

But both the structure share very little sequence similarity. Their length also vary.

22 September 2021 9,791 3 View