Rachal Cmp

9 Questions 6 Answers 0 Followers

Questions related from Rachal Cmp

What is the difference between LC-MS and Direct Infusion Mass Spectrometry?

Dear all, May i know what is the difference between LCMS and DIMS ? I have sent all my chemically synthesized compounds for DI-MS analysis. However, i found out that most of the journals are...

14 April 2018 3,325 3 View

What is the difference between crude type and purified enzyme?

Dear all, Anybody could explain to me what is the difference between crude type and purified enzyme? Why the IC50 value for both enzyme would be different when tested on particular inhibitor? Your...

10 April 2018 3,507 8 View

What are the chemistry journal websites that accept negative bio-assay result?

Anybody could suggest me any journal website that possibly accept negative bio-assay result in the research study has done? The project included computer modelling (docking study), chemical...

02 January 2018 1,628 3 View

What is the relationship between EC50 and IC50? Isn't it possible generate IC50 from EC50 value?

Dear all, As far as i know, EC50 is the concentration of a drug that gives half-maximal response. The IC50 is the concentration of an inhibitor where the response (or binding) is reduced by half...

25 July 2017 8,918 2 View

Does the distances of coordination bond formed between ligand and metal affect the binding affinity?

Dear all, May i know does the distance of coordination bond between ligand and metal affect the binding affinity? What would be the acceptable range for the coordination bond distance? I am...

21 July 2017 6,938 2 View

Why the calculated m/z value from chemdraw is different from the exact mass spectrometry value?

Dear all, I have a compound with molecular formula C11H9BrN2O3S2, the molecular weight is about 361.23 Da, the predicted m/z value from chemdraw is 361.92 (100%), 359.92 (94.0%), however my real...

25 June 2017 4,388 6 View

What is the reason behind we have to add hydrogen atoms during the protein optimization for molecular docking?

Dear all, Currently i am running docking studies using AutodockTools 4.2. For the protein optimization stage, why do we need to add hydrogen atoms as well as charges into the protein? What is the...

06 June 2017 5,050 3 View

Some of my carbon peak doesnt appear but proton nmr peak is complete, why?

i have the full set nmr result for my compound included 1H, 13C, dept, cosy, hsqc & hmbc. However, some of my carbon peak (all quaternary C) didnt appeared. One of the proton showed...

20 February 2017 6,998 10 View

Does anybody can give me some idea what is that unknown peak in my NMR spectrum?

I have synthesized two different compounds. However, what a coincident both nmr spectrum showed an unknown peak (singlet, very intense) at the region of 2.4 - 2.6 ppm in proton nmr, 28 - 30 ppm in...

18 January 2017 6,102 9 View