Prasad Gobburi

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Questions related from Prasad Gobburi

How can different mobile phases effect on peak shapes in LC-MS analysis?

Peak shape and resolution was not good when I used acetonitrile on C18 column in method development of my compound. But using methanol as mobile phase gave good peak shape. What would be the reason?

12 November 2014 2,295 7 View

How can one solve the problem of a huge carryover issue during LC-MS analysis of a drug candidate?

I tried different analytical reverse phase columns ,different mobile phases with different time programs , different needle wash solutions . But I could not solve the problem. Adding low...

12 November 2014 5,828 7 View