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Need to see whether the drug binds to minor groove of DNA by a simple agarose gel electrophoresis in presence of ethidium bromide. Any experimental suggestions?
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I am working with urea-polyacrylamide denaturing gel for p32 lebelled oligonucleotide reaction with some drug in presence of topoisomerase IB in TBE 1X. The image of the gel is not so clear, does...
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