Peter J Cossar

4 Questions 6 Answers 0 Followers

Questions related from Peter J Cossar

Preparing Vilsmeier reagent?

Dear Research Gate community, I am currently attempting to install a formyl group using the Vilsmer-Haak reaction on a 2,4- substituted thiophene. The reaction was adapted from a reference,...

20 July 2019 8,583 3 View

Has anyone conducted decoupled STD NMR?

Hi Research gate community, I'm interested in conducting decoupled STD NMR to maximize the signal to noise. Does anyone know how I can do this or if I can simply edit the parameters of the...

26 March 2019 9,719 5 View

Does anyone have and electronic version of the Topsin user manual for 3.6.1 so that I can educate myself on STD-NMR or alternatively a SOP?

I am looking to set up a Fragment based screening using STD NMR. Our NMR scientist is currently in the process of updating our topspin software to 3.6.1. Does anyone have and electronic version of...

23 January 2019 1,839 3 View

Does anyone have experience with trouble shooting hanging drop crystallography?

Hi all, I am currently working on 14-3-3 sigma protein. I have obtained good diffraction (2.15 A) from a sitting drop Bis-tris propane (BTP) screening plate. The conditions are 26% PEG400, 5%...

08 January 2019 2,172 7 View