Parnaz Merikhian

6 Questions 8 Answers 0 Followers

Questions related from Parnaz Merikhian

Looking for IHC staining on scFv antibody?

Hi, Has anyone tried immunohistochemistry (IHC) staining on your constructed single-chain variable fragment (scFv) antibody? If you had done that before, could you please explain what's the best...

07 July 2018 4,095 1 View

Antibody internalization after fixation with paraformaldehyde in cell ELISA assay?

Hi, An antibody specific to the extracellular domain of HER2 receptor was produced. It is used as both target protein and primary antibody on SKBR3 cell ELISA assay in order to confirm its binding...

06 June 2018 9,847 2 View

MUC1 overexpression cancer cell lines?

Hi, If anyone can help me on finding out a list of different types of cancer cell lines that aberrantly overexpress the cell surface associated mucin1 (MUC1) proto-oncogene and the percentages of...

21 December 2017 9,234 4 View

What could be adverse effects of using cell therapy strategies for breast cancer treatments?

While early screening and advances in treatment have allowed breast cancer patients to overcome their disease, these treatments often have side effects that can reduce patient's survival. Also,...

11 November 2017 8,585 3 View

Which receptors can form heterodimer with HER (erbB) family receptors, HER 1-4, in breast cancer?

Hyper-activation of the HER family receptors, leads to up-regulation of the three vital signaling pathways, such as PI3K-AKT or MAPK pathways. It has been demonstrated that one of the reason for...

25 July 2017 1,549 4 View

What is the effect of inhibiting mucin1 (MUC1) transmembrane protein on HER2 gene expression in trastuzumab-responsive breast cancer cells?

The transmembrane mucin 1 (MUC1) onco-protein is aberrant overexpressed in breast cancer cells and associates with HER2.It has been demonstrated that silencing MUC1-C in HER2-overexpressing breast...

05 July 2017 6,571 2 View