Can I use Crispr-Cas9 system for a simple deletion of an amino acid residue (to desactivate the actif center of a gene)? and does it work randomly ?

I'm confused because Crispr-Cas9 system can lead to significant on-target mutagenesis, such as frequent large-fragement deletions (kilobase scale).

27 March 2024 7,042 1 View