Why do microbiota composition results from MOTHUR and CLC Genomics workbench pipeline differ so much, even with the same reference database?

Our samples had been analysed by Mothur + Silva 119 reference DB around 2015. When analysing the same samples in 2023 with CLC genomics workbench and SILVA 119 DB, the results are strikingly...

22 March 2024 990 1 View