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Questions related from Matheus Andrade Meirelles
I'm running a phosphorylation reaction to produce an organic phosphate salt as my product. Structure RPO(OH)(ONBu4). After isolating the pure product, I want to fully deprotonate the phosphate and...
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Dear community, I'm having a lot of trouble trying to obtain 2,4-diaminopyrimidines to my PhD project. The best way I could find so far to introduce the 2 amino groups is through double SNAr...
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One of the molecules I designed to synthesized is a alpha, beta unsaturated lactone with a halogen alpha to the carbonyl. To construct the lactone I'm planning to perform a RCM reaction; however,...
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I have a pdb file with a ligand and a protein linked covalently. It is a cysteine residue. I know that to run a covalent docking this bond is needed. However, when I import the pdb to GOLD...
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I'm using a procedure that uses morpholine and DIBAL-H. First I make the complex intermediate of the aluminum (1eq of DIBAL) with the morpholine (1eq) by stirring them for 3 hours. Then, I add my...
01 September 2016 5,719 21 View
Well, I already know that this reagent is a little bit tricky because of the quench part but my problem is that in a chlorination of alcohol using POCl3 I do TLC and it looks like all the start...
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