PKa1 and pKa2 for ethylene diamine are 9.92 and 7.11 - does binding of the first ammonium group to an anion lead to an apparently higher second pKa?

Primary amines are strong bases, but vicinal diamines have, due to charge repulsion between vicinal ammonium groups, a pronouncedly lower 2nd pKa. For ethylene diamine, pKa1 and pKa2 are 9.92...

16 September 2021 9,783 0 View