Marco Bolis

5 Questions 9 Answers 0 Followers

Questions related from Marco Bolis

RNASeqV1, RNASeqV2, AlexaSeq could you point out pros/cons?

I'm working on an RNASeq batch of data and I'm interested in discriminating gene isoforms. I performed the analysis using the classic tuxedo suite bowtie+tophat+cufflinks. I've seen many papers...

21 March 2014 2,729 4 View

Are there some databases / portals that are specifically aimed to collect protein array data?

I could find some experiments searching for "Proteomic profiling by array" in GEO and array-express, but I'm wondering if there is more outside or if that is all for now?

13 March 2014 2,794 6 View

Does anyone have experience with Multi-Omics Interaction Network (GE + miRNA + Methylation + CNA)?

I determined the sensitivity of 40 breast cancer cell lines to a previously untested chemical compound. For each of the cell lines (before treatment) I have multiple Omics data: Gene Expression,...

05 March 2014 9,273 8 View

Is mtry=1 acceptable for a randomForest model based on 23 predictors?

I created my first randomForest model (regression) in order to predict sensitivity to a particular drug in breast cancer cell lines. Total features were 35000 and I used default mtry for...

09 February 2014 7,858 3 View

Are p-values computed from variable importances (randomForest) usable for meta-analysis?

I have several gene-expression datasets and would like to perform a meta-analysis by combining p-values using Fisher's method. I used to perform this using p-values derived from differential...

29 October 2013 1,840 2 View