Lamya Alghanim

4 Questions 2 Answers 0 Followers

Questions related from Lamya Alghanim

How can I block michael acceptor group from reacting with nitrogen during synthesis?

There is a Michael acceptor in one substrate that could potentially react with amine in the second substrate, how can I block this reaction? is there any blocking group for Michael acceptor.

21 August 2023 658 2 View

Which in vitro assay can I use to know if the tested compound acts as an allosteric inhibitor of GPCR ?

I want to develop negative allosteric inhibitors of CCR2 , which is one of the GPCR , what in-vitro assay is used to know if the tested compound acting as allosteric modulator?

18 July 2023 4,143 1 View

Can I use MTT assay or Sulforhodamine B (SRB) assay to measure the cytotoxicity of CCR2 inhibitors in pancreatic cell lines ?

I have virtually searched for compounds that bind to CCR2 receptors. I have also planned to perform binding studies to determine the effect of those compounds as agonist or antagonist. Compounds...

29 May 2023 5,224 0 View

How can I interpret the following results of a homology model ?

I came across these results from a paper about homology model: verify 3D score = 104 verify 3D expected high score = 127.341 , verify 3D expected low score = 57.303. What do these results indicate?

04 May 2021 4,535 3 View