Why can trypsin activate PAR1-PAR4 and tryptase only PAR2?

Both enzymes belong to the trypsin family of serine proteases and both have a substrate specificity for argynyl and lysyl residue-containing substrates. I know that PAR 2 has a SKGR34↓S35SLIGKV...

21 May 2015 6,979 3 View