Jose Antonio Vargas

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Questions related from Jose Antonio Vargas

Does anyone have any preclinical or clinical experience w/3-Bromo-Pyruvate as add on Tx w/standard chemotherapy in cancer cells?

A common feature of some advanced cancers is their enhanced capacity to metabolize glucose to lactic acid. Some carcinoma cells express highly glycolytic phenotype depending on the expression of...

12 August 2015 1,448 9 View

Is there still any room for symptom control improvement concerning acid reflux control in GERD?

An upcoming new class of acid secretion inhibitors called potassium-competitive acid blockers (P-CAB) which competitively inhibits the binding of potassium ion to H+, K+-ATPase (proton pump) in...

06 August 2015 9,677 1 View

Does anyone in the RG community know the mechanism of diarrhea caused by metformin?

Apparently the molecular mechanisms underlying diarrhea caused by metformin is due to an increase in intestinal chloride secretion through apical chloride channels. This is semi regulated process...

28 July 2015 1,629 16 View

Does any clinical gastro-researcher have any experience w/pinaverium bromide, otilonium bromide or cimetropium for IBS treatment?

Our IBS Mexican research working group has been working on a couple of CTs w/a b.i.d. 100mg pinaverium bromide + 300mg dimethicone dose combination at both 4 & 12 week treatment w/positive...

22 July 2015 2,039 8 View

Does anyone have any experience with Trichuris suis (pig whipworm eggs) for treating IBD-UC and its relation with IL-17 & IL-22?

Treating refractory IBD a-UC with anti TNF alpha AB seems not to be the right answer for most of the developing countries specially in Latin American populations, due to the high pharmacoeconomic...

27 February 2015 9,582 2 View