For those working on systematic reviews: how do you handle high heterogeneity (I² > 75%) in your meta-analyses when a random-effects model still show?

In some of the meta-analyses I've worked on, even after applying a random-effects model, the heterogeneity remains very high (I² > 75%), and the confidence intervals stay wide. In such cases,...

12 June 2025 3,608 2 View