Jianzhong Ma

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Questions related from Jianzhong Ma

Does any annotation tools provide information on which allele is the deleterious one for a Loss-of-function variant?

It seems that all the well-known annotation tools implicitly assume that the reference allele (identical to the allele of the human reference genome) is the normal one and the functional...

15 August 2018 5,210 5 View

Did all reads in one of the two fastq files generated by Illumina paired end sequening come from the same strand (either forward or reverse)?

I found in the .bam files, in any region (even though known as non-inverted region), the following bitwise FLAG number, 83,163, 99,147, are almost equally distributed (close to 25% each), implying...

03 December 2014 6,521 3 View