Jagadeesh Babu Thentu

3 Questions 7 Answers 0 Followers

Questions related from Jagadeesh Babu Thentu

How to screen SSRIs- selective serotonin reuptake inhibitors, with behavioral pharmacology as a measure?

The animal model should depict that the mechanism is through serotonin re-uptake transporter.

17 October 2019 4,830 6 View

Kindly comment, In which condition do both the parent and its metabolite exposures increase in a given particular body fluid following parent dose?

Observed a relative increase in both parent and its metabolite exposures in body fluids following intake of parent form in rats. The increase was observed in highest test dose compared to lowest dose.

24 May 2019 3,002 3 View

Does the exposure (EC50 brain or plasma) level of a drug at 50% of response (efficacy) vary with route of drug administration in pre-clinical animals?

I am with a view that plasma or brain exposure of a CNS drug remain same at ED50 when it was dosed orally or subcutaneously... But I am not with such result, plz justify the reason for variability..

11 May 2015 734 18 View