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The animal model should depict that the mechanism is through serotonin re-uptake transporter.
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Observed a relative increase in both parent and its metabolite exposures in body fluids following intake of parent form in rats. The increase was observed in highest test dose compared to lowest dose.
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I am with a view that plasma or brain exposure of a CNS drug remain same at ED50 when it was dosed orally or subcutaneously... But I am not with such result, plz justify the reason for variability..
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