Heiko Brennenstuhl

4 Questions 3 Answers 0 Followers

Questions related from Heiko Brennenstuhl

Is there a database or table of all known gene-disease associations (with disease groups)?

Dear all, I have a list of about 800 genes and I would like to annotate associated disorders/diseases. If possible, I would like to add some disease groups as well (e.g. if the disorder is an...

02 September 2023 4,077 5 View

How do you find absolute numbers of variants detected in a gene of interest?

This question keeps me busy - is there any database or any other scientifcically valid way to determine the frequency of disease-causing variants within a given gene? Most publications on this...

19 December 2019 9,190 0 View

Help on Variant Call Format file for CADD Score determination?

Hi everyone, I would like to use the CADD Score to determine the deleteriousness of novel genetic variants. The web interface requests a VCF file as input file type, unfortunately, I do not know...

23 January 2019 636 0 View

How do you calculate Gibb's Free Energy for a tetrameric protein?

I am using FoldX suite as a plugin in Yasara to calculate the difference in free energy caused by specific mutants in a protein I am interested in. I end up with ΔGmut and ΔGwt and calculate ΔΔG =...

16 January 2019 8,891 7 View