Gustavo Finatti Sakamoto

5 Questions 4 Answers 0 Followers

Questions related from Gustavo Finatti Sakamoto

Can a weighted linear regression be compared to the unweighted regression when assessing lack of fit in bioanalytical method validation?

Can the weighted model be considered the full model and the unweighted model the reduced model? Or should the structure of the full model contain a more complex term (e.g., polynomial) for an...

3 weeks ago 4,642 2 View

What type of residuals should be used to check the assumptions of normality and homoscedasticity in weighted linear regression?

Hello, I am working with weighted linear regression for calibration curves (testing different weighting factors) and trying to understand what is the correct approach to check regression...

3 weeks ago 5,580 3 View

Is it plausible to use different weighting schemes when working with two different biological matrices using the same equipment (LC/MS-MS)?

Hello, My question is in the context of bioanalytical method validation using plasma and brain homogenate. Different weighting schemes (1, 1/x, 1/x^2, 1/y and 1/y^2) were tested and the...

3 weeks ago 1,744 1 View

What are the practical explanations for using weighting factors in the response variable "y" (e.g., 1/y or 1/y^2) in bioanalytical method validation?

My question is in the context of testing and choosing the best weighted linear regression for a calibration model (calibration curves using an internal standard). How to explain the use of the...

06 February 2025 9,539 3 View

Does spline interpolation consider censored data when working with data below the limit of quantification?

Nonlinear mixed-effects models (may) consider data below the limit of quantification (BLQ) in parameter estimation. However, an evaluation of the goodness-of-fit plots (observations vs predictions...

11 May 2021 781 3 View