Filip Fratev

2 Questions 13 Answers 0 Followers

Questions related from Filip Fratev

Is there at all an "open" helix 12 apo conformation in PPARγ?

Hi, In many X-ray structures, including this of the apo PPARγ, the receptor was solved in a homodimer in which the chain B showed helix 12 in an "open" conformation whereas the chain A was almost...

02 March 2015 1,331 2 View

Estrogen receptor alpha H12 transforms from "Apo" to Agonist or even Antagonist conformation only after dimmer formation?

Hi all, I performed totally of +1 us Accelerated MD (aMD) of ERa starting from the "Apo" structure (pdb id:1a52) such as many before me. However, the aMD approach speed-up the simulations around...

28 December 2012 3,458 3 View