Has anybody experienced the elevating of apparent permeability coefficient of Caco-2 cells with long period of transport experiment (up to 5 h)?

I did transport experiments across Caco-2 cell monolayers for 2 periods within 5 hours (2.5 h of each period). With transport of the same substance different period of experiment, Papp increased....

08 August 2015 6,992 2 View