Chenxiao Tang

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Questions related from Chenxiao Tang

Does Ki of an inhibitor change based on different substrates of an enzyme?

For example, will Ki of cimetidine change based on different CYP3A4 substrate?

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How to rank new chemical entities based on their chemical properties and PK properties?

For example, during the process of CNS lead optimization, compounds will be measured for potency, selectivity, CYP inhibition profile, solubility, BBB permeability, toxicity, etc. How are the...

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