Bharath Srinivasan

4 Questions 54 Answers 0 Followers

Questions related from Bharath Srinivasan

Is it common that the mass of the N-terminal methionine is missing in an ESI-MS spectra of the intact protein recombinatly expressed in E. coli?

I seem to be consistently getting a mass of 34167.5 instead of 34298.7 for my recombinantly expressed intact protein ( expressed in E. coli). This corresponds to an exact loss of a methionine...

04 May 2016 9,544 6 View

Can a group of structurally-related inhibitors show different mechanisms of inhibition for the same receptor protein?

I am working with a group of inhibitors that were obtained by scaffold hopping. However, I would like to clarify that they do not make up a QSAR series. Detailed inhibition kinetics performed with...

17 March 2016 3,246 4 View

What is the solubility of 1-fluoro-4-[2-(4-fluorophenyl)ethenyl]benzene?

I have ordered the above mentioned compound. Before I carry out any experiments, I would want to know details about its solubility and the nature of solvent that it dissolves in. There is no...

04 February 2016 1,534 1 View

Are QSAR studies relevant in drug discovery given the rapid advent of x-ray crystallography?

Given the ease of doing x-ray crystallography & solving complexed structures and given that it gives a snap-shot of ligand protein interactions, do you think that indirect deductions through...

01 April 2015 5,571 5 View