Ashu Gupta

4 Questions 7 Answers 0 Followers

Questions related from Ashu Gupta

How can I dissolve active pharmaceutical ingredients of paracetamol (Acetaminophen) to induce hepatotoxicity in mice/rats (PCM: 500mg/kg b.w., p.o.)?

I am trying to dissolve API of Acetaminophen in Saline/Water to induced Hepatotoxicity in Mice/Rats. But it not dissolved. PCM is soluble in Ethanol and DMSO. May I use Ethanol/DMSO to dissolve...

08 August 2014 4,571 21 View

Is it possible to check the acute toxicity of CCL4 in Olive oil (1:1) directly after 24 hrs of CCl4 administration?

Is it possible to check the Acute toxicity of CCL4 in Olive oil (1:1) directly after 24 hrs of CCl4 administration (1ml/kg, i.p; CCL4 in Olive oil; 1:1) in Toxic Group of Mice instead of giving...

07 July 2014 9,941 4 View

Why does the level of AST and ALT decrease as compared to normal control animal (Balb/c, Male, 23 g) group (PCM and CCL4 induced Hepatotoxicity)?

I am using the standard protocol for Paracetamol (PCM: Tablet from Cipla: 250 and 500 mg/kg oral) and CCL4 (in Olive oil; 0.5 and 1.5 ml/kg i.p.) induced Acute Hepatotoxicy. Blood was...

07 July 2014 6,209 9 View

Testing hepatic toxicity without an animal model

To replace animal use in testing hepatic toxicity of a drug on trial, which one of the following would be used in vitro closest to be closest to the in vivo? My options are: 1. Liver cells 2....

07 July 2012 6,932 19 View